Euclidean Norm in Composite Severity Score to Evaluate an Allergic Reaction from Conjunctival Provocations
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چکیده
The conjunctival provocation test (CPT) is a diagnostic procedure for testing airborne allergens causing allergic rhinoconjunctivitis [1,2]. It has been thoroughly evaluated with regard to its precision [3] and compared with nasal provocation tests [4]. Nowadays, the CPT is used for evaluation of allergic rhinoconjunctivitis [5,6] and is accepted by regulatory authorities as an outcome parameter in dose-finding trials.
منابع مشابه
Allergic conjunctivitis and conjunctival provocation tests in atopic dogs.
INTRODUCTION Canine atopic dermatitis (cAD) is a very common disease, but little is known about eye involvement. The conjunctival provocation test (CPT) is used in human to study the ocular response to allergenic stimuli and to evaluate anti-allergic therapy. To our knowledge it has not been used in dogs. OBJECTIVES To evaluate the prevalence of ocular signs in a population of atopic dogs and...
متن کاملJapanese guidelines for allergic conjunctival diseases 2017.
The definition, classification, pathogenesis, test methods, clinical findings, criteria for diagnosis, and therapies of allergic conjunctival disease are summarized based on the Guidelines for Clinical Management of Allergic Conjunctival Disease (Second Edition) revised in 2010. Allergic conjunctival disease is defined as "a conjunctival inflammatory disease associated with a Type I allergy acc...
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AIM To study the effect of the topical anti-inflammatory drug, ketorolac, on (1) the clinical allergic reaction induced by the conjunctival provocation test (CPT); (2) the release of tryptase in tears; and (3) the expression of adhesion molecules on the conjunctival epithelium. METHODS 10 allergic but non-active patients were challenged in both eyes with increasing doses of specific allergen ...
متن کاملAnti-inflammatory and antiallergic eVects of ketorolac tromethamine in the conjunctival provocation model
Aim—To study the eVect of the topical anti-inflammatory drug, ketorolac, on (1) the clinical allergic reaction induced by the conjunctival provocation test (CPT); (2) the release of tryptase in tears; and (3) the expression of adhesion molecules on the conjunctival epithelium. Methods—10 allergic but non-active patients were challenged in both eyes with increasing doses of specific allergen to ...
متن کاملPeak nasal inspiratory flow as outcome for provocation studies in allergen exposure chambers: a GA2LEN study
BACKGROUND The GA2LEN chamber has been developed as a novel mobile allergen exposure chamber (AEC) allowing standardized multicenter trials in allergy. Hitherto, subjective nasal symptom scores have been the most often used outcome parameter, but in standardized modern trials objective parameters are preferred. Despite its practicability, the objective parameter peak nasal inspiratory flow (PNI...
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تاریخ انتشار 2014